The second SOS Children's Village in Panama is located at a distance of 150 km away from the country's capital of Panama City on the outskirts of the province's capital of Penonomé. SOS Children's Village Penonomé is just off the Pan-American Road. The place was chosen because of the social difficulties of this region. The rural area around Penonomé does not offer enough employment to all families. This is why many leave their children behind in order to search for work elsewhere.

SOS Children's Village Penonomé became operational in 1990; the official opening took place in April 1991 in the presence of SOS Children's Villages' president Mr Helmut Kutin. The buildings, which have been set up in a circle on a building site of about 50,000 sq m, are idyllically surrounded by little hills. The SOS Children's Village consists of twelve family houses, the village director's and other co-worker's houses, a library, a sewing room and a community building which includes an office. A large part of the site is used for agricultural purposes: fish farming, small animal breeding, fruit and vegetable plantations. Within easy reach of the SOS Children's Village, there are schools, a hospital and the national university.

Apart from that, an SOS Youth Facility was set up in the city centre of Penonomé in 1996. It comprises a number of youth communities where young people live together cared for by a youth supervisor and prepare for their future independence.